January 2012
SCIENCE & TECHNOLOGY
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During a training exercise, National CBRNE response team (RCMP and Canadian Forces), wearing bomb suits, investigate a container after the detection of a possible radiological dispersal device.

Security Science and Technology for the Next Decade

The events of September 11, 2001, highlighted that free and open democratic societies are vulnerable to attacks. It brought home the pressing need to find more effective ways of protecting North America and its allies. In Canada, a group of innovative federal scientists led a unique effort to build previously non-existent capabilities (knowledge, tools, methods, and experts) to counter new domestic terrorist threats, especially potential weapons of mass destruction, including chemical, biological, radiological, and nuclear (CBRN) agents.

Recognizing that no single player could address these threats alone, the government established a collaborative, nation-wide approach shepherded by the CBRNE Research and Technology Initiative, which later became a program under the Defence R&D Canada Centre for Security Science.

This approach was based on the fact that Canadian expertise in areas like emergency and specialized response, defense, public and animal health, food safety, domestic radiological protection, environmental response, intelligence, law enforcement, and other public safety fields, were spread across government, universities, and industry. This meant that scientists and technical experts from these different backgrounds would have to work together to ensure the best minds were tackling Canada's security challenges.

As the global media shone its spotlight on epidemics, fires, earthquakes, hurricanes, cyber-attacks, criminal activity, environmental accidents, and foreign radiological events, it became clear that the dangers to domestic security went well beyond terrorist threats. Efforts were expanded to focus on issues like critical infrastructure protection, cyber-security, surveillance, intelligence, border security, and emergency management systems (people, tools, and processes), while broadening the scope to all types of hazards, including terrorism, criminal activities, accidents, and natural disasters.

The impact of these efforts was highlighted in the years leading up to the Vancouver 2010 Winter Games and the G8 and G20 Summits in June 2010 when the federal S&T community played a critical role in supporting security partners, ensuring that they had access to the appropriate scientific advice and support for event planning and during the events themselves. This included the co-location of scientific advisors in operations centers, as well as the equipping and manning of mobile nuclear, biological, forensics, and chemical labs.

In the 10 years since 9/11, the global and domestic security landscape has evolved significantly. Keeping pace with this evolution, the Canadian security S&T community has worked hard to strengthen the nation’s ability to weather all types of natural and man-made hazards. Looking into the future, these developments will ultimately serve to enhance public confidence and ensure that the men and women who contribute to a population’s safety and security are equipped with the cutting-edge knowledge, tools, and processes they need.

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Dr. Michael Pollak.

Solving the Mystery of an Old Diabetes Drug that May Reduce Cancer Risk

In 2005, news first broke that researchers in Scotland had found unexpectedly low rates of cancer among diabetics taking metformin, a drug commonly prescribed to patients with Type II diabetes. Many follow-up studies reported similar findings, some suggesting as much as a 50-percent reduction in risk. How could this anti-diabetic drug reduce the risk of developing cancer, and what were the mechanisms involved?

In a paper published this month in the journal Cancer Prevention Research, researchers from McGill University and the University of Montreal reported an unexpected finding: they learned that exposure to metformin reduces the cellular mutation rate and the accumulation of DNA damage. It is well known that such mutations are directly involved in carcinogenesis, but lowering cancer risk by inhibiting the mutation rate has never been shown to be feasible.

“It is remarkable that metformin, an inexpensive, off-patent, safe, and widely used drug, has several biological actions that may result in reduced cancer risk,” said Dr. Michael Pollak, Professor in McGill's Departments of Medicine and Oncology, researcher at the Lady Davis Institute for Medical Research at the Jewish General Hospital, and the study's director. “These latest findings suggest that it reduces mutation rate in somatic cells, providing an additional mechanism by which it could prevent cancer.”

The study, carried out in collaboration with the laboratory of Dr. Gerardo Ferbeyre at University of Montreal Department of Biochemistry, suggests that metformin reduces DNA damage by reducing levels of reactive oxygen species (ROS). ROS are known to be DNA-damaging agents produced as by-products when cells generate energy from nutrients. This action appears to take place in mitochondria, the cellular organelles that produce energy in cells by "burning" nutrients. Past studies have identified the mitochondria as a site of action for metformin related to its anti-diabetic function, but those studies had not considered that the drug also acted here to reduce ROS production, thereby reducing the rate at which DNA damage accumulates. "We found that metformin did not act as a classic antioxidant," said Dr. Ferbeyre. "The drug seems to selectively prevent ROS production from altered mitochondria such as those found in cells with oncogenic mutations."

"This study opens an exciting new direction in cancer-prevention research," said Dr. Pollak. "This doesn't imply, however, that metformin is now ready to be widely used for cancer prevention. We do not yet know if the drug accumulates to sufficient concentrations in human tissues at risk for cancer, such as breast or colon, when taken at the usual doses used for diabetes treatment, nor do we know if the findings from the original studies showing reduced cancer risk, which were carried out in diabetics, also apply to people without diabetes.”

That said Dr. Pollak points out that the possibility of protecting DNA from oxidative damage by the use of a well-tolerated drug was not expected and that the topic deserves further study at many levels.

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About UBC

The University of British Columbia (UBC), established in 1908, is one of Canada’s leading research universities and is consistently ranked among the top 40 in the world. The university attracts 54,000 students from across Canada and 140 countries around the world to its two major campuses.

 

UBC Researchers Identify Potential New Therapy Approach for Hepatitis C that Could Benefit 170 Million People Worldwide

Researchers at the University of British Columbia (UBC) have found a new way to block infection from the hepatitis C virus (HCV) in the liver that could lead to new therapies for those affected by this and other infectious diseases.

More than 170 million people worldwide suffer from hepatitis C, the disease caused by chronic HCV infection. The disease affects the liver and is one of the leading causes of liver cancer and liver transplant around the world. HCV is spread by blood-to-blood contact, and there is no vaccine to prevent it. Current treatments for the disease are only moderately effective and can cause serious side effects.

“As HCV infects a person, it needs fat droplets in the liver to form new virus particles,” says François Jean, Associate Professor in the Department of Microbiology and Immunology and Scientific Director of the Facility for Infectious Disease and Epidemic Research (FINDER) at UBC. “In the process, it causes fat to accumulate in the liver and ultimately leads to chronic dysfunction of the organ. HCV is constantly mutating, which makes it difficult to develop antiviral therapies that target the virus itself, so we decided to take a new approach.”

Mr. Jean (pictured above) and his team developed an inhibitor that decreases the size of host fat droplets in liver cells and stops HCV from “taking residence,” multiplying and infecting other cells. “Our approach would essentially block the lifecycle of the virus so that it cannot spread and cause further damage to the liver,” he said.

HCV is one of a number of viruses that require fat to replicate in the human body. This new approach to curbing the replication of HCV could translate into similar therapies for other related re-emerging viruses that can cause serious and life-threatening infections in humans, such as dengue virus. Dengue is endemic in more than 100 countries, with approximately 2.5 billion people at risk of infection globally. In some countries, Dengue has become the leading cause of child mortality.

The UBC research was supported by the Canadian Institutes of Health Research (CIHR) through grants and scholarships and by the Michael Smith Foundation for Health Research (MSFHR) through its Junior Trainee Award.

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Engineering for Earthquakes

Canada’s seismic activity is monitored by Natural Resources Canada, which maintains a network of 160 seismographs that monitor earthquakes and measure ground movement in all parts of the country. This information feeds into the National Building Code of Canada, which serves as a model to help provincial and territorial authorities ensure that structures are engineered to the level of earthquake hazard for their locale.

 

Other Countries Benefitting from Canada’s Earthquake Research

At 2:46 p.m. on March 11, 2011, Japan's northeast coast was shaken by a magnitude 9.0 earthquake, the largest ever recorded in the country's history. Twenty-six minutes later, towering tsunami waves rolled in. As of June 2011, more than 14,000 people are thought to have died, although the true tally may never be known. The World Bank ranks it as the world's costliest natural disaster, with economic damage estimated at $235 billion.

The Indian Ocean tsunami, on the morning of December 26, 2004, was triggered by an even larger magnitude earthquake (9.2). It was much deadlier, claiming the lives of more than 250,000 people in 14 countries bordering the Indian Ocean. The economic cost of $14 billion, however, was far less than in Japan, “partly because of low property and land values in the affected areas,” according to The Economist.

These cases illustrate the reality of natural disasters in the 21st century, says Dr. John Clague, Canada Research Chair in Natural Hazards and Director of the Centre for Natural Hazards at Simon Fraser University. “In poor countries, deaths from natural disasters are increasing, while in wealthy countries, economic damage from natural disasters is increasing.”

In Canada, happily, there have been no major earthquakes to date that have led to large-scale property destruction and personal injury or death. Many of the country’s major urban centers, however, are vulnerable to earthquakes to some degree.

The west coast is Canada's most seismically active area: of the approximately 4,000 earthquakes recorded annually in Canada, half occur in or offshore British Columbia.  This puts Vancouver and Victoria at the top of the list of urban centers at risk. But Montreal, Ottawa, Toronto, and Quebec City are all at risk of an earthquake as well.

The Canadian Risk and Hazards Network has concluded that a significant earthquake is Canada's greatest potential natural disaster, seeing as much of our urban infrastructure predates the seismic-based building codes introduced in the 1970s. The magnitude 6.7 Northridge, California, earthquake in 1994 illustrates the level of damage that could occur on Canada's West coast under similar circumstances. It left 60 people dead, 7,000 injured and more than 40,000 buildings damaged in Los Angeles and surrounding counties.

Although it's not yet possible to predict exactly when and where an earthquake will occur, Canadian scientists are carrying out a range of geophysical studies, both on land and offshore, to develop reliable prediction methods.

At Natural Resources Canada, one project with strong potential benefits uses global positioning satellite technology to measure clusters of miniscule tremors along faults that form where the Juan de Fuca tectonic plate is being forced under (or subducted beneath) the North American Plate. This is Canada's most earthquake-prone region, and great earthquakes of magnitude 9.0 or higher occur here on average every 500 to 600 years, the last one being in 1700.

These clusters of miniscule tremors, known as “episodic tremor and slip” events, were first identified by seismologists at the Geological Survey of Canada in 2003. They occur like clockwork every 12 to 16 months and last for several weeks.

While more research is required to fully understand these events, seismologists are certain that they are a key to improving forecasts of when and where the next great earthquake will occur in the region. Other countries, such as Japan and Chile, with similar geological environments, are adapting this Canadian discovery to their own research.

Another project is taking advantage of NEPTUNE, one of Canada's most exciting big science projects. NEPTUNE has wired a 497-mile loop on the seafloor of the Juan de Fuca Plate and sprinkled it with instruments that allow scientists of all disciplines to conduct experiments via the Internet.

Using NEPTUNE, researchers at Natural Resources Canada have set up a deep-water seismograph network that records real-time seismic activity on the Juan de Fuca Plate. This data is fed into the land-based Canadian National Seismograph Network, which is used to determine the size and location of earthquakes as they happen.

Dr. Clague suggests there could be another interesting theoretical application. Should a big earthquake occur at the plate interface, it would be picked up by the NEPTUNE seismometers in real time and transmitted to shore stations, arriving as much as a minute before the earthquake hit Victoria or Vancouver.

Granted a minute is not much time, but Japan had that much advance warning from their monitoring systems at the start of the March 2011 earthquake. This gave them enough time to shut down their railways, preventing the possible derailment of high-speed trains due to the shaking and averting another level of human tragedy.

The Earth is in constant motion, full of tremors and twitches, as its plates push into and under each other. Dr. Clague points out that earthquakes, devastating as they can be, are just part of the natural order. "Science and engineering can help us to understand earthquakes and live more safely with them,” he says. “But at the individual level, we have to know the basics of emergency preparedness, so if an earthquake strikes we will have a better chance of getting ourselves and our loved ones through it."

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